Instant disintegrating tablets (IDTs) have emerged as a promising oral drug delivery system to enhance patient compliance, particularly in pediatric, geriatric, and dysphagic populations. The present research focuses on the formulation and in-vitro evaluation of instant disintegrating tablets of Sitagliptin phosphate, an oral hypoglycemic agent used in the management of type 2 diabetes mellitus, employing Plantago ovata mucilage as a natural superdisintegrant. Tablets were prepared by the direct compression method and evaluated for pre-compression and post-compression parameters including flow properties, hardness, friability, wetting time, drug content, in-vitro disintegration time, and dissolution behavior. The developed formulations exhibited rapid disintegration, satisfactory mechanical strength, and enhanced drug release profiles. The study demonstrates that Plantago ovata mucilage is an effective, economical, and biocompatible natural superdisintegrant for the development of instant disintegrating tablets of Sitagliptin phosphate, offering improved patient compliance and therapeutic performance.
Instant disintegrating tablets, Sitagliptin phosphate, Plantago ovata, natural superdisintegrant, type 2 diabetes mellitus.
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